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Water; Drinking Water of Ancient Rome
it is thought by many experts that because the Romans lined their water pipes and cooking vessels with lead, it seriously effected their brains.
Lead is a powerful neurotoxin affecting electrical nerve activity - lowering IQ and disrupting behaviour. It could possibly be argued that the extent of this mental instability caused by water contamination helped lead to the fall of the Roman Empire.
It should be remembered that the emperor Caligula (12-41 AD) appointed his horse as consul and himself as Jupiter, King of the gods, and he was by no means the only Roman ruler to be classified as mentally frail.